According to the FDA: "Between 1999 and October 2008, 32 reports of serious liver injury, including 6 cases of liver failure, in patients using orlistat were submitted to FDA’s Adverse Event Reporting System. "
The FDA has not advised doctors change their prescribing practices with orlistat and say consumers currently taking Xenical should continue to take it as prescribed. Those using over-the-counter Alli should continue to use the product as directed as well.
However, the FDA says consumers should consult their doctor if they experience symptoms that could possibly be associated with the use of orlistat and development of liver injury, particularly weakness or fatigue, fever, jaundice or brown urine. Other symptoms may include abdominal pain, nausea, vomiting, light-colored stools, itching, or loss of appetite.
To report adverse affects you may visit the MedWatch Online Report provided by the FDA.
Related Reading: All About Alli
